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Additional resources for Acute Respiratory Distress Syndrome, Second Edition, Volume 233 (Lung Biology in Health and Disease)
Ventilator-associated lung injury in patients without acute lung injury at the onset of mechanical ventilation. Crit Care Med 2004; 32:1817–1824. Montgomery AB, Stager MA, Carrico CJ, et al. Causes of mortality in patients with the adult respiratory distress syndrome. Am Rev Respir Dis 1985; 132:485–489. Knaus WA, Sun X, Hakim RB, et al. Evaluation of definitions for adult respiratory distress syndrome. Am J Respir Crit Care Med 1994; 150:311–317. Ciesla DJ, Moore EE, Johnson JL, et al. Decreased progression of postinjury lung dysfunction to the acute respiratory distress syndrome and multiple organ failure.
The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. N Engl J Med 1997; 336:912–918. National Center for Injury Prevention and Control. Scientific Data, Surveillance, and Injury Statistics. gov/injury (accessed February 2009). Rainer TH, Lam PK, Wong EM, et al. Derivation of a prediction rule for post-traumatic acute lung injury. Resuscitation 1999; 42:187–196. Behrendt CE. Acute respiratory failure in the United States: incidence and 31-day survival.
The authors further controlled for Acute Physiology and Chronic Health Evaluation (APACHE) in the septic patients and injury severity in the trauma patients without a significant effect on the attributable mortality. The evidence linking mortality to ALI is not uniform and may be risk factor dependent. After adjusting for age, severity of illness, and injury severity, ALI was not statistically significantly associated with mortality in patients sustaining severe trauma. The signal was particularly attenuated after excluding patients who died in the first 24 hours from their initial injury (35).