By Gunhild Waldemar, Alistair Burns
A part of the Oxford Neurology Library sequence, this moment variation of Alzheimer's Disease is a succinct and sensible advent to the analysis, assessment and administration of Alzheimer's sickness. This useful pocketbook comprises 14 absolutely up to date chapters on key issues corresponding to pathophysiology, epidemiology, pharmacological remedies, and mental signs. The advent of recent chapters on strange shows, end-of-life matters, and case vignettes make sure the reader is absolutely outfitted with the most recent realizing of the potential factors of the ailment, tools of analysis, and administration thoughts. content material is gifted in a concise and straightforward to learn layout designed for speedy reference, with invaluable key issues indexed at first of every chapter.
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Extra resources for Alzheimer's disease
The intersection of amyloid beta and tau at synapses in Alzheimer's disease. Neuron 204;82:756-–7. of Alzheimer’s disease References CHAPTER 2 Pathophysiology Acknowledgements SJA is a Sigmund Gestetner Senior Research Fellow. Thanks is given for the support of Bristol Research into Alzheimer’s Disease (BRACE), the Alzheimer’s Society, and the Sigmund Gestetner Trust. g. Introduction Dementia is a disabling syndrome characterized by progressive deterioration in multiple cognitive domains that is severe enough to interfere with daily functioning, including social and professional functioning.
3 Genetic risk factors Other risk factors have become known due to the Genome Wide Association Studies (GWAS) in which large numbers of individuals are examined for common genetic variants to highlight any associations with the disease. Approximately 30 polymorphisms have been identified as significantly lowering or increasing the age of onset of sporadic AD. This includes proteins involved in immune function including CR (complement component (3b/4b) receptor ) and TREM2 (triggering receptor expressed on mye14 loid cells 2), and cholesterol metabolism and transport such as APOE, clusterin (apolipoprotein J), and ABCA7.
Further to this, an RXR agonist bexarotene has been shown to upregulate APOE and lipid transporters and to increase phagocytosis by macrophages and microglia, resulting in increased clearance of Aβ. 3 Genetic risk factors Other risk factors have become known due to the Genome Wide Association Studies (GWAS) in which large numbers of individuals are examined for common genetic variants to highlight any associations with the disease. Approximately 30 polymorphisms have been identified as significantly lowering or increasing the age of onset of sporadic AD.