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By M. Maurer

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A double-blind, placebo-controlled trial of TRH in amyotrophic lateral sclerosis. Neurology, Vol. 36, No. 2, pp. 141-145. K. D. (2010). Cannabis and amyotrophic lateral sclerosis: hypothetical and practical applications, and a call for clinical trials. Am J Hosp Palliat Care, Vol. 27, No. 5, pp. 347-356. M. & Stambler, N. (1997). Performance of the Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS) in multicenter clinical trials. J Neurol Sci, Vol. 152 Suppl 1, pp. S1-9. C. C. (2010).

A doubleblind placebo-controlled trial of L-threonine in amyotrophic lateral sclerosis. J Neurol, Vol. 239, No. 2, pp. 79-81. , d'Ydewalle, C. & Van Den Bosch, L. (2011). Amyotrophic lateral sclerosis and excitotoxicity: from pathological mechanism to therapeutic target. CNS Neurol Disord Drug Targets, Vol. 9, No. 3, pp. 297-304. W. B. (1987). Interrater reliability of a modified Ashworth scale of muscle spasticity. Phys Ther, Vol. 67, No. 2, pp. 206-207. D. (1997). Amyotrophic lateral sclerosis: lessons in trial design from recent trials.

In ALS patients, an involuntary weight loss of more than 10 percent of the original body weight correlates with an increased mortality. Thus treatment with olanzapine might increase the body weight, or, at least, keep it constant. Currently, olanzapine is evaluated in a phase II/III study (NCT00876772) in ALS patients. , 2010; Martin, 2010). Currently, olesoxime is evaluated in a phase II/III trial (NCT00868166) as add-on to riluzole and a phase II/III safety extension study (NCT01285583). , 1982).

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